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Scientific literature references Anavar (Oxandrolone) as a synthetic androgen derivative developed to explore structural modifications of dihydrotestosterone analogs. Research publications commonly examine its molecular stability, receptor-binding behavior, and metabolic resistance resulting from the 2-oxa substitution and 17-alpha modification. Analytical studies frequently use Oxandrolone as a comparator compound in structure–activity relationship (SAR) research, oral bioavailability assessments, and non-aromatizable androgen models. Across decades, peer-reviewed work has emphasized its predictable analytical profile, reproducibility in controlled conditions, and suitability for chromatography- and spectrometry-based validation rather than broad physiological modeling.