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Navigation-guided craniotomy integrates preoperative CT/MRI data with intraoperative tracking, enabling surgeons to tailor skull openings with sub-millimeter precision. This method significantly reduces invasive exposure and operative time, optimizing craniotomy size, minimizing blood loss, and preserving neurological function . Navigation-guided craniotomy enhances surgeon confidence by virtually “walking through” the anticipated surgical corridor and clarifying tumor-eloquent region boundaries . Image guidance is especially critical for deep-seated lesions and skull-base tumors, improving safety and outcomes while reducing hospital stays.